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Thursday, May 31, 2012

The AJC reviews The Pullman, Kirkwood | Food and More with John ...

$-$$

Back in the late 2000s, 1992 Hosea Williams Drive was home to the quintessential Kirkwood bar, Aces Bar & Grill. Representative of the influx of young gentrifiers, the smoky dive bar served the local 20-somethings well. But times change and 20-somethings grow up. Enter The Pullman.

Review by Jon Watson

Partners and Kirkwood locals Heidi Shonkwiler and Dan Wingate set out to open a community-centric gastropub to match the evolving demographic of Kirkwood. When the pair learned that Aces was going under ?after a weeks-long stint as the kid-friendly Jak?s All In,? they saw their opportunity to build the pub the neighborhood needed. No longer an adults-only dive bar, The Pullman aims to offer a place to share a few pints with friends, as well as a place to park your stroller while you do it.

The Pullman walks that 30-something line between family-friendly enough to bring the kids along for dinner, but young enough to draw the crowd back in for drinks once the little ones are in bed. Wingate and Shonkwiler teamed up with chef Lotinza Clark from Radial Cafe to create a sampling of seasonal pub grub, offering a late-night menu most nights until midnight or later.

Unlike many self-declared gastropubs, shareable small plates are not the focus here, concentrating instead on sandwiches and entrees. The Oh George ($10), the house burger, comes with a man-sized half-pound patty of local beef, thick bacon slices, manchego cheese and a remarkably fresh yet mild jalapeno mayo. I?m pleasantly surprised by the special of the day: a fried chicken sandwich ($10) on toast, topped with tomato and mixed greens, oozing on all sides with melted pimento cheese.

Sriracha wings (photos by Becky Stein)

Among the appetizers, a plate of the Sriracha wings ($8) makes for a great starter to split with friends. The sweet and spicy glazed wings keep just enough of the unmistakable kick of the rooster sauce, tempered just enough to satisfy heat lovers without alienating more timid palates. I was more than happy to hog most of our plate of chicken livers ($6), enjoying the light, flash-fried batter dusted with fresh herbs.

You?ll hear no complaints of small portions when the server airlifts the barbecue short ribs ($13) to your table. This impossibly large slab of slow-roasted beef arrives slathered with peach barbecue sauce atop a sweet potato and plantain hash, and can easily feed two adults. At seeing the shocked look in my eyes my server swears, almost apologetically, that I received the largest rib she?d seen them serve. This eats almost like a moist, braised brisket. Taken in human-sized portions, each bite is excellent, but I couldn?t help but picture some starving child across the world as I returned a plate with 2 pounds of meat still on it.

Peach BBQ Short Rib

For a place claiming the gastropub title, I wish the beer selection was a little more extensive, currently offering 12 draft beers and a handful of bottles. However, half of the taps are dedicated to local breweries, and the rest offer a rotating selection of some more obscure beers that should keep most craft brew-heads interested.

Cocktails also get the seasonal treatment, and regularly change. The current menu offers multiple light libations, like the Palace ($8), a summery mix of gin, St. Germain and ginger ale, perfect for sipping on a warm afternoon. Or, spice things up a bit with the tequila-based Lightning Slinger ($8), mixed with pineapple juice, ginger liqueur and a dash of coarse ground black pepper.

A few missteps hint that the crew is still getting their feet under them . The blue cheese mayo is noticeably absent from my blackened chicken sandwich ($9) when I peel back the bun, and a bowl of spinach, artichoke and smoked gouda dip ($7) begs for a few more shakes of salt.

While the service is consistently attentive, I couldn?t help but notice the kitchen fall behind at seemingly odd times. One crowded Sunday brunch, I had no trouble getting my plate of peppered steak and eggs ($12), but on a slow Tuesday evening with only a handful of occupied tables, a plate of falafel and hummus ($7) arrives as we pay our check (for which our repentant server did not charge us.)

The Pullman aims to be the pub where all walks of the community can gather, and at that, they surely succeed. Shonkwiler and Wingate know their neighbors well, and have crafted a cozy little neighborhood tavern that everyone in the Kirkwood area should check out.

THE PULLMAN 1992 Hosea Williams Drive N.E., Kirkwood, 404-371-1115

Food: Seasonal pub grub
Service: Friendly, but still working out the kinks
Best dishes: Oh George and Sriracha wings
Vegetarian selections: Most appetizers and salads, and many can be made veggie by request
Credit cards: Visa, Mastercard and Discover
Hours: 4 p.m.-1 a.m. Mondays-Wednesdays, 4 p.m.-3 a.m. Thursdays-Fridays, 10 a.m.-
3 a.m. Saturdays, 10 a.m.-midnight Sundays.
Children: more than welcome
Parking: technically, street parking only and can get very tight.
Reservations: no
Wheelchair access: yes
Smoking: no
Noise level: moderate to loud
Patio: no
Takeout: yes

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Researchers identify a 'life-and-death' molecule on chronic leukemia cells

Public release date: 30-May-2012
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Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center

SMIP-016 is a promising experimental drug that kills chronic leukemia cells.
The drug targets a protein called CD37, but it wasn't known how this kills leukemia cells.
This study showed unexpectedly that CD37 helps regulate both cell-death and cell-survival signals, explaining how the drug works and how it might be improved.
COLUMBUS, Ohio A new study has identified a life-and-death signaling role for a molecule on the surface of the immune cells involved in the most common form of chronic leukemia. The finding could lead to more effective therapy for chronic lymphocytic leukemia (CLL), an as yet incurable cancer that occurs in more than 16,000 Americans annually.

The study, led by researchers at the Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James), examines how an experimental drug called SMIP-016 kills CLL cells.

Earlier work by the same researchers showed that the drug targets a molecule called CD37, which is found on the surface of CLL cells. In this new study, the researchers discovered that the CD37 molecule has two regions that can concurrently activate two separate pathways in CLL cells, one that leads to cell death and another that promotes cell survival.

The findings show SMIP-016 activates the "death" part of the molecule, and they suggest that blocking the "survival" part of the molecule could improve the drug's effectiveness, the researchers say.

The study is published in the May issue of journal Cancer Cell.

"These findings open new possibilities for the use of immune-based therapy for treating CLL," says principal investigator Dr. John Byrd, a CLL specialist and professor of Medicine, of Medicinal Chemistry and of Veterinary Biosciences.

"We are already targeting the cell-death pathway using SMIP-016, and we might be able to optimize the drug's effectiveness by simultaneously blocking the cell-survival region of the molecule with a second antibody," he says.

Byrd notes that drugs that can block the cell-survival pathway already exist.

"We were very surprised and excited to find that CD37 is directly involved in regulating survival and cell-death pathways," says first author Rosa Lapalombella, a research scientist in Byrd's laboratory. "That's not usually the case for molecules of this kind."

Co-principal investigator Dr. Natarajan Muthusamy, associate professor of Medicine, notes that CD37 belongs to a family of molecules called tetraspanins, which usually only facilitate signaling by bringing together other molecules that when combined issue signals.

"This work is a great example of collaborative research involving several laboratories," says researcher and co-principal investigator Dr. Michael Freitas, associate professor of molecular virology, immunology and medical genetics, whose laboratory contributed to the global proteomic work of how CD37 signals. "The support for, and emphasis on, team science is a major driving strength of Ohio State and contributed to this project's findings," he says.

Byrd hopes to begin a clinical trial soon that tests SMIP-016 combined with a drug that blocks the survival pathway.

"Overall, these findings reinforce our belief SMIP-016 could be an effective agent for treating CLL and other malignancies that sometimes express the CD37 protein, including non-Hodgkin's lymphoma and acute lymphoblastic leukemia," says Byrd, who is the D. Warren Brown Chair of Leukemia Research.

###

Funding from the Leukemia and Lymphoma Society, the NIH/National Cancer Institute (grant nos. CA140158, CA095426, CA133250, and CA107106), Mr. and Mrs. Michael Thomas, the Harry Mangurian Foundation and the D. Warren Brown Foundation supported this research.

Other researchers involved in this study were Yuh-Ying Yeh, Liwen Wang, Asha Ramanunni, Sarwish Rafiq, Shruti Jha, Justin Staubli, David M. Lucas, Rajeswaran Mani, Sarah E.M. Herman, Amy J. Johnson, Arletta Lozanski, Leslie Andritsos, Jeffrey Jones, Joseph M. Flynn, David Jarjoura, Xiaokui Mo, Dasheng Wang, Ching-Shih Chen, Gerard Lozanski, Nyla A. Heerema, Susheela Tridandapani and Michael A. Freitas of The Ohio State University; Brian Lannutti of Gilead Pharmaceuticals Inc; Peter Thompson of OrbiMed Advisors; and Paul Algate and Scott Stromatt of Emergent BioSolutions.

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Researchers identify a 'life-and-death' molecule on chronic leukemia cells Public release date: 30-May-2012
[ | E-mail | Share ]
Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center

SMIP-016 is a promising experimental drug that kills chronic leukemia cells.
The drug targets a protein called CD37, but it wasn't known how this kills leukemia cells.
This study showed unexpectedly that CD37 helps regulate both cell-death and cell-survival signals, explaining how the drug works and how it might be improved.
COLUMBUS, Ohio A new study has identified a life-and-death signaling role for a molecule on the surface of the immune cells involved in the most common form of chronic leukemia. The finding could lead to more effective therapy for chronic lymphocytic leukemia (CLL), an as yet incurable cancer that occurs in more than 16,000 Americans annually.

The study, led by researchers at the Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James), examines how an experimental drug called SMIP-016 kills CLL cells.

Earlier work by the same researchers showed that the drug targets a molecule called CD37, which is found on the surface of CLL cells. In this new study, the researchers discovered that the CD37 molecule has two regions that can concurrently activate two separate pathways in CLL cells, one that leads to cell death and another that promotes cell survival.

The findings show SMIP-016 activates the "death" part of the molecule, and they suggest that blocking the "survival" part of the molecule could improve the drug's effectiveness, the researchers say.

The study is published in the May issue of journal Cancer Cell.

"These findings open new possibilities for the use of immune-based therapy for treating CLL," says principal investigator Dr. John Byrd, a CLL specialist and professor of Medicine, of Medicinal Chemistry and of Veterinary Biosciences.

"We are already targeting the cell-death pathway using SMIP-016, and we might be able to optimize the drug's effectiveness by simultaneously blocking the cell-survival region of the molecule with a second antibody," he says.

Byrd notes that drugs that can block the cell-survival pathway already exist.

"We were very surprised and excited to find that CD37 is directly involved in regulating survival and cell-death pathways," says first author Rosa Lapalombella, a research scientist in Byrd's laboratory. "That's not usually the case for molecules of this kind."

Co-principal investigator Dr. Natarajan Muthusamy, associate professor of Medicine, notes that CD37 belongs to a family of molecules called tetraspanins, which usually only facilitate signaling by bringing together other molecules that when combined issue signals.

"This work is a great example of collaborative research involving several laboratories," says researcher and co-principal investigator Dr. Michael Freitas, associate professor of molecular virology, immunology and medical genetics, whose laboratory contributed to the global proteomic work of how CD37 signals. "The support for, and emphasis on, team science is a major driving strength of Ohio State and contributed to this project's findings," he says.

Byrd hopes to begin a clinical trial soon that tests SMIP-016 combined with a drug that blocks the survival pathway.

"Overall, these findings reinforce our belief SMIP-016 could be an effective agent for treating CLL and other malignancies that sometimes express the CD37 protein, including non-Hodgkin's lymphoma and acute lymphoblastic leukemia," says Byrd, who is the D. Warren Brown Chair of Leukemia Research.

###

Funding from the Leukemia and Lymphoma Society, the NIH/National Cancer Institute (grant nos. CA140158, CA095426, CA133250, and CA107106), Mr. and Mrs. Michael Thomas, the Harry Mangurian Foundation and the D. Warren Brown Foundation supported this research.

Other researchers involved in this study were Yuh-Ying Yeh, Liwen Wang, Asha Ramanunni, Sarwish Rafiq, Shruti Jha, Justin Staubli, David M. Lucas, Rajeswaran Mani, Sarah E.M. Herman, Amy J. Johnson, Arletta Lozanski, Leslie Andritsos, Jeffrey Jones, Joseph M. Flynn, David Jarjoura, Xiaokui Mo, Dasheng Wang, Ching-Shih Chen, Gerard Lozanski, Nyla A. Heerema, Susheela Tridandapani and Michael A. Freitas of The Ohio State University; Brian Lannutti of Gilead Pharmaceuticals Inc; Peter Thompson of OrbiMed Advisors; and Paul Algate and Scott Stromatt of Emergent BioSolutions.

[ | E-mail | Share ]
?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

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Gaspari Nutrition- MyoFusion - Muscle Works Magazine

When it comes to the REAL nutritional needs of bodybuilders and athletes alike, there is little doubt what ?legitimate? science has to say about the different protein sources available in the supplement marketplace. Unfortunately, this has little to do with the marketing message spread by most sellers of protein supplements today. The competition between companies is fierce and the drive to sell more protein by differentiating a product by any means necessary (whether it?s legitimate science or not) is prevalent to say the least. MyoFusion? delivers only the highest and most legitimately bioavailable proteins in existence ? hard and fast.

Atkins Advantage

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Diet program for mass building

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The Zone Diet

The Zone is one of those diets that has scientists scratching their heads ? many say that it is working because people are simply eating less junk food. But for whatever reason, it has been of enormous help to so many people now that its effectiveness can?t be doubted. Created by Dr. Barry Sears, the [...]

Saying good night at peace, get to sleep

Insomnia is a common problem that is said to affect today?s generation Y people largely, irrespective of men, women, and children. Well, causes can range from being under stress and anxiety to leading a hectic and misbalanced lifestyle. Whatever the reason might be, the main concern focuses around the question how to get to sleep [...]

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Video: Betting Against Facebook

Kim Forrest, Fort Pitt Capital Group, explains why she is telling her clients to stay away from Facebook.

Aaron Sorkin On Steve Jobs Movie: Taking An Artistic View Of The ...

Aaron Sorkin is an Academy and Emmy award winning writer and producer.

Hollywood screenwriter Aaron Sorkin was interviewed today by Walt Mossberg at the D10 conference in California. Sorkin has been hired by Sony to adapt Walter Isaacson?s official biography of Steve Jobs, and he has already tapped Apple co-founder Steve Wozniak to help advise him during the production process.

Sorkin talked about writing his Jobs movie today onstage. He described his writing process and how he wants to approach the film. After affirming that the film is still in the earliest stages of production, Sorkin talked about how he wants the audience to relate to his script and the kind of actor he wants to play Jobs.

To Sorkin, writing a script is a ?process of procrastination where you try to figure out what the movie is going to be about.? Echoing what he said earlier on the Jobs biopic, Sorkin remarked that ?it?s very difficult to shake the cradle-to-grave structure of a biography.? Instead, Sorkin wants to ?identify the point of friction that appeals to me and dramatize that.?

How long before Sorkin?s screenplay is ready for filming? ?I?m at the earliest possible stage,? Sorkin said. ?I?ll go through a long period that would not look to any causal observer like writing. It would look more like watching ESPN probably.? Sorkin was referring to the process of researching and gathering information on the late Apple co-founder.

?One of the hesitations I had in taking on the movie is that it was a little like writing about The Beatles,? said Sorkin. ?There are so many people out there who know so much about him and who revere him. I just saw a minefield of disappointment.? Sorkin has hope, however. ?Hopefully when I?m done with my research I?ll be in the same ballpark of knowledge about Steve Jobs.?

?Anytime you go to the movies and see ?the following is a true story?, you should think of it as a painting, not a photography,? said Sorkin. The Social Network, an Oscar-winning film on Facebook?s Mark Zuckerberg written by Sorkin, is the perfect example of what Sorkin refers to as ?taking an authorial view? of history. It?s a dramatization, not play-by-play snapshots of history.

Walt Mossberg of The Wall Street Journal and Sorkin onstage at D10.

When asked who would play Jobs in his movie with Sony, Sorkin said that the role had not yet been cast. ?They [the actor] are going to have to talk fast,? Sorkin said, referring to the intense way of speaking Jobs used to communicate. The actor will also have to be very smart, according to Sorkin. ?Actors can fake a lot of things, but intelligence is something you can?t fake.?

Ashton Kutcher, an actor known for his comedic roles in shows like That 70?s Show, is also starring in an indie Jobs biopic that will be out later this year, and Sorkin acknowledges the project by saying that Steve Jobs is a big enough persona for there to be ?room for more than one movie.?

?Steve Jobs is an extremely complicated guy,? said Sorkin. ?I know this for sure: I can?t judge the character.? Sorkin said that he has to ?find the parts of him [Jobs] that are like me? to defend the character.??With a character like Steve Jobs, you want to write the character as if they are making the case to God why they should be allowed into heaven.?

Source: AllThingsD

Prototype iPad sells for $10,200 on eBay

12 hrs.

Devin Coldewey

An early prototype of the iPad with a surprising design quirk has sold for just?over $10,000 on eBay. The device features two dock connection ports, something that was rumored for the iPad 2. Unfortunately, the novelty of the two ports will be somewhat dampened by the fact that this iPad only runs a testing platform called Switchboard instead of iOS.

As the seller describes it:

This is one of a VERY small amount of Apple prototype devices and you rarely see these on ebay. This iPad has 16GBs of capacity, and is incredibly unique?...?Apple prototyped these iPads to have this connector late in the process and at the last minute decided to remove them. There are patent drawings and leaked casings that show the indents for both dock connector holes, but this unit has both dock connectors, and both are full functional for charging this iPad and connecting it to your computer.

There were certainly rumors to the effect that a new iPad would have two ports, and as the seller notes there were actually leaked cases and drawings that showed this design. This particular iPad, however, is the first actual device to show up with the ports intact.

Whether Apple indeed intended to include both ports up until "the last minute" is anyone's guess, though it seems unlikely that Steve Jobs and Jonathan Ive, both decisive and minimalistic in their design tendencies, would allow such an ambiguity into a shipping product.

It is, however, possible and even likely that the decision of which side the dock would be on was left until the last minute, as the device is equally usable in both landscape and portrait modes. They settled?on portrait as the primary orientation, clearly, mirroring the iPhone and differentiating the iPad from widescreen monitors and TVs.

Interestingly, as a commenter points out at MacRumours, which found the listing, the circuitry necessary for the second dock connector is still present in normal iPads, though there is no hole in the case through which it can be accessed.

The real question, of course, is how did this device get out of Apple's labs in the first place? The seller tells Wired: "Judging by how Apple works, it?s most likely stolen, but I?m not sure about that...?I can?t give much information about the Apple device without revealing who specifically I am." That may put this auction in questionable legal territory.

Regardless, the package is already in the open, in transit?to the US-based buyer. Apple may try to track it down, but this cat is already out of the bag.

Devin Coldewey is a contributing writer for msnbc.com. His personal website is coldewey.cc.

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Cook Reveals More Details About Apple?s Product Naming Policies, And Yes, The ?S? Stands For Siri

Apple's product naming polices can be somewhat confusing and arbitrary: And today an audience member at D10 called Apple CEO Tim Cook out on the somewhat bizarre strategy, "How did you guys go from an iPad to an iPad 2 to an iPad 4 to a 4s?" "A lot of people ask me that question," he said.

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Wednesday, May 30, 2012

Why swine flu virus is developing drug resistance

ScienceDaily (May 29, 2012) ? Computer chips of a type more commonly found in games consoles have been used by scientists at the University of Bristol to reveal how the flu virus resists anti-flu drugs such as Relenza and Tamiflu.

Professor Adrian Mulholland and Dr Christopher Woods from Bristol's School of Chemistry, together with colleagues in Thailand, used graphics processing units (GPUs) to simulate the molecular processes that take place when these drugs are used to treat the H1N1-2009 strain of influenza -- commonly known as 'swine flu'.

Their results, published May 29 in Biochemistry, provide new insight that could lead to the development of the next generation of antiviral treatments for flu.

H1N1-2009 is a new, highly adaptive virus derived from different gene segments of swine, avian, and human influenza. Within a few months of its appearance in early 2009, the H1N1-2009 strain caused the first flu pandemic of the 21st-century.

The antiviral drugs Relenza and Tamiflu, which target the neuraminidase (NA) enzyme, successfully treated the infection but widespread use of these drugs has led to a series of mutations in NA that reduce the drugs' effectiveness.

Clinical studies indicate that the double mutant of swine flu NA known as IRHY2 reduced the effectiveness of Relenza by 21 times and Tamiflu by 12,374 times -- that is, to the point where it has become an ineffective treatment.

To understand why the effectiveness of Relenza and Tamiflu is so seriously reduced by the occurrence of this mutation, the researchers performed long-timescale molecular dynamics (MD) simulations using GPUs.

Professor Mulholland said: "Our simulations showed that IRHY became resistant to Tamiflu due to the loss of key hydrogen bonds between the drug and residues in a part of the NA's structure known as the '150-loop'.

"This allowed NA to change from a closed to an open conformation. Tamiflu binds weakly with the open conformation due to poor electrostatic interactions between the drug and the active site, thus rendering the drug ineffective."

These findings suggest that drug resistance could be overcome by increasing hydrogen bond interactions between NA inhibitors and residues in the 150-loop, with the aim of maintaining the closed conformation.

The research was supported by the Engineering and Physical Sciences Research Council (EPSRC) through a Leadership Fellowship grant to Professor Mulholland and a software development grant to Professor Mulholland and Dr Woods.

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The above story is reprinted from materials provided by University of Bristol.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

Christopher J. Woods, Maturos Malaisree, Naruwan Pattarapongdilok, Pornthep Sompornpisut, Supot Hannongbua, Adrian J. Mulholland. Long Time Scale GPU Dynamics Reveal the Mechanism of Drug Resistance of the Dual Mutant I223R/H275Y Neuraminidase from H1N1-2009 Influenza Virus. Biochemistry, 2012; 51 (21): 4364 DOI: 10.1021/bi300561n

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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U.S. expels top Syrian diplomat, rejects intervention

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UN envoy discusses peace plan with Syrian leader

BEIRUT (AP) ? International envoy Kofi Annan is meeting with President Bashar Assad to discuss the peace plan meant to end the country's 15-month-old crisis.

That plan appears increasingly shaky following a massacre of more than 100 people, many of them women and children, last week. The U.N. said government forces fired tank shells and artillery at the villages that make up Houla, but stopped short of blaming them for the killings.

Activists said most of the dead were killed by pro-government thugs who stormed the area.

The Houla killings prompted sweeping international condemnation and the harshest language yet from Syrian ally Russia ? making it a potential turning point in the crisis that has killed more than 9,000 people.

The meeting between Annan and Assad is taking place Tuesday in Damascus.

THIS IS A BREAKING NEWS UPDATE. Check back soon for further information. AP's earlier story is below.

BEIRUT (AP) ? A weekend massacre of more than 100 people emerged as a potential turning point in the Syrian crisis Monday, galvanizing even staunch ally Russia to take an unusually hard line against President Bashar Assad's government.

Analysts said Russia may be warning Assad that he needs to change course or lose Moscow's support, which has been a key layer of protection for the Syrian government during the uprising that began in March 2011.

Russia has grown increasingly critical of Damascus in recent months, but Foreign Minister Sergey Lavrov's latest comments were unusually strong. Although he said opposition forces have terrorists among them, he put the blame for 15 months of carnage primarily on Assad's government.

"The government bears the main responsibility for what is going on," Lavrov said in Moscow following a meeting with British Foreign Secretary William Hague. "Any government in any country bears responsibility for the security of its citizens."

Alexei Malashenko, a Middle East expert with the Carnegie Moscow Center, said Lavrov's comments suggest Russia may be backing away from its long-standing support for Damascus.

"Bashar Assad is driving himself and Russia into a corner," Malashenko said. "Bashar has definitely gotten the sense that he may lose Russia's sympathy, and he may step back a bit."

It is not clear whether Assad's forces were exclusively to blame for the slaughter of 108 people Friday in Houla, a collection of poor farming villages in Homs province. The United Nations said 49 children and 34 women were among the dead; some had bullet holes through their heads.

The U.N. Security Council blamed Syrian forces for artillery and tank shelling of residential areas, but it did not clearly state who was responsible for the close-range shooting deaths and "severe physical abuse" of civilians.

Activists from the area said the army pounded the villages with artillery and clashed with local rebels. They said pro-government gunmen later stormed the area, doing the bulk of the killing by gunning down men in the streets and stabbing women and children in their homes.

The Syrian government rejected that account entirely, saying soldiers were attacked in their bases and fought back in self-defense without leaving their bases.

Russia blamed both the government and the rebels for the Houla massacre.

"Both sides have obviously had a hand in the deaths of innocent people, including several dozen women and children," Lavrov said. "This area is controlled by the rebels, but it is also surrounded by the government troops."

He said Russia has no interest in propping up Assad but wants Syria to guide its own transition under a plan brokered by special envoy Kofi Annan.

"We don't support the Syrian government; we support Kofi Annan's plan," Lavrov said.

Moscow's pro-Syria stance has been motivated in part by its strategic and defense ties to Damascus, including weapons sales. Russia also rejects what it sees as a world order dominated by the U.S.

Losing Russian support could be disastrous for Assad because his crackdown has left him almost completely isolated internationally. Russia and China have stood by him so far, using their veto power to block U.N. resolutions against him.

Hilal Khashan, a political science professor at the American University of Beirut, said the Houla massacre appears to be ushering in a change in Russia's position.

"There is a shift and the momentum against the regime is gathering," Khashan said. "The momentum is building and the Russians are not blocking the rising momentum."

The Syrian conflict is among the most explosive of the Arab Spring, in part because of Syria's allegiances to powerful forces, including Lebanon's Hezbollah and Shiite powerhouse Iran.

Activists say as many as 12,000 people have been killed since the uprising began. The U.N. put the toll as of March, a year into the uprising, at 9,000, but many hundreds more have died since.

Annan's peace plan, which calls for a cease-fire and dialogue, has been faltering for weeks. But Western leaders have pinned their hopes on his diplomatic pressure, since the U.S. and others are unwilling to get deeply involved in another Arab nation in turmoil.

Annan arrived in Damascus on Monday for talks with Assad and other officials and called on "every individual with a gun" in Syria to lay down arms, saying he was horrified by the Houla massacre.

Britain's Prime Minister David Cameron and French President Francois Holland spoke on the phone and expressed their desire to work with Russia to resolve the crisis in Syria. A British spokeswoman said Cameron and Hollande agreed to act together to "bring an end to the bloody suppression of the Syrian people."

Activists reported fresh violence Monday, saying troops shelled several neighborhoods in Hama, killing at least 24 people.

___

Berry reported from Moscow. AP writers Bassem Mroue in Beirut and Vladimir Isachenkov in Moscow contributed to this report.

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Deleted Scenes: Alien hunter redirects her search to Earth-based funding

SETI scientist Jill Tarter retires from research to focus on raising funds to continue search for extraterrestrial life

Web edition : Tuesday, May 29th, 2012

Imagine if E.T. phoned Earth and heard, ?We?re sorry, no one is here to take your call right now. Please try again later.? Or if, after traveling for thousands of years, radio signals carrying the imprint of an alien technological civilization fell on dormant Earthly ears.

These possibilities could become reality if funding forces the Search for Extraterrestrial Intelligence to turn off the telescopes and quit searching for the answer to one of humankind?s most profound questions.

Jill Tarter isn?t going to let that happen.

After 35 years of eavesdropping on the stars, hoping to hear the intelligent murmurings of an extraterrestrial civilization, the SETI Institute?s lead alien hunter is hanging up her receiver and retiring as director of the Center for SETI Research.

But she?s not quitting the quest.

Instead of querying the heavens for signs of life, Tarter will query life on Earth for the funds needed to keep Earth?s ears online. ?We?re just going to make this a crusade,? she told me during an interview. (You can read it here.)

Physicist Gerry Harp has taken the reins from Tarter, the SETI Institute announced on May 22. ?It?s been challenging and exciting, a lot of new things to learn, a lot of new meetings to go to,? Harp says of his new role. ?But from what I?m seeing, Jill?s working at least as hard as she ever did before. I think we should acknowledge that she is still very much a part of the program.?

Tarter?s curiosity about life on other worlds erupted in the 1970s, fueled by a serendipitous merging of her ability to program a very old computer (a PDP-8/S ? ?I always thought the ?S? stood for ?stupid,?? she says), with a forward-looking proposal to find out whether other communicating civilizations exist in the galaxy. At the time, Tarter was in graduate school at the University of California, Berkeley. ?I couldn?t imagine anything more exciting or rewarding than trying to answer this old question,? Tarter says. ?I got hooked and I stayed hooked.?

In 1984, Tarter and several colleagues founded the SETI Institute, a nonprofit organization that has since grown to include more than a hundred people. Once focused mainly on detecting radio signals from extraterrestrial civilizations, the institute now employs scientists studying many factors important for the existence of alien life ? from Kepler team members who are detecting and characterizing exoplanetary systems, to astrobiologists searching for life in the most extreme environments on Earth and in the solar system?s exotic nooks and crannies.

But the institute needs money to keep searching. Once funded by a fraction of a percentage of NASA?s budget, SETI has relied on private donors to maintain the interstellar dial tone since 1993 ? courtesy of one senator, who killed any substantial SETI funding for the foreseeable future. ?For years, we became the four-letter S-word that you couldn?t actually say at NASA headquarters,? Tarter recalls.

Now, with the Allen Telescope Array ? a SETI array comprising 42 dishes (out of a planned 350) ? that funding is more crucial than ever. Last April, the array went into hibernation after funds dried up. In October, the array returned to operations, propelled by individual donors who contributed more than $200,000. Now, the telescope is under new management by SRI International, and is supported by a contract from the U.S. Air Force that tasks it with searching for orbiting space trash.

Still, 50 percent of the observing time is occupied with SETI searches. ?For SETI, it is the best thing around,? Harp says. ?We have 12 hours a day on this telescope. It?s very difficult to get 12 hours a day on any telescope in the world, and that?s what we have.?

Tarter is hoping to once again tap the enthusiasm of SETI supporters and build a lifeline that will support the search for centuries. ?SETI really is the investment in our future,? she said. ?If we detect a signal, we know we can have a long lifetime.? There will be proof that it is possible to become an old technology. Someone else did it. Therefore, damn it, we can do it.?

See the whole Q&A here.

Found in: Astronomy and Atom & Cosmos

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Fast-growing construction firm Willmott Dixon opens new office ...

Construction firm Willmott Dixon has relocated its Bristol office to Pill on the city?s outskirts having outgrown its Queen Square premises.

The? 4,000 sq ft base on the Eden Office Park will house the firm?s 50-plus employees ? a major increase on the four staff Willmott Dixon had when it opened its first Bristol office in 2004.

Despite the recession and the knock-on effect on the construction industry, Willmott Dixon has continued to win new business in the South West, which has fueled its continued recruitment programme.

Willmott Dixon South West and Wales managing director Neal Stephens said: ?Our move not only reflects the success we?ve had in the past decade but shows our continued determination to grow and adjust to difficult market conditions.

?Our new offices are perfectly situated near junction 19 of the M5 allowing easy access to our projects in the South West.

?With a growing team, we have opted for a much larger office space which will accommodate our expansion in the future.?

Turnover for the South West and Wales region rose from ?100m in 2010 to ?110m last year. The company has a strong presence ?in both the public and private sectors.

Pictured: John Boughton and Neal Stephens outside Willmott Dixon's new offices

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Increasing Home Resale Value thru New Roofing

Buying a house is probably one of the biggest investments you will ever make in your life. When you plan to move to a new home and sell your current one, you have to make sure that you will get the most money out of it. One way to do this is by increasing the resale value of your home.

Think back to the time when you first bought your house in Manchester. The first thing you may have observed is the appearance of the home's exterior. Aesthetics have a significant impact on house sales, thus, a more beautiful house has a higher resale value. To get the most money out of selling your home, you have to make a good first impression on buyers; you have to take care of the curb appeal.

There are many things you can do to increase the resale value of your home. For instance, you have to make sure that the exterior of your house looks neat. Also keep in mind that you have to consider how the other houses in your neighborhood looks like. You may consider having your front lawn or backyard landscaped or you can remodel some sections of the house. If there are any old or worn out components, replace them immediately. Take the roof as an example; not only does it affect the visual appeal of your home, but it also plays a great role in weather protection.

Replacing an old, damaged roof does not just increase the curb appeal of your home, but it also provides better functionality. New roofing also offers better protection and insulation; this greatly adds to your home's resale value. If you plan to do this, you have to find reliable roofing companies and choose the appropriate roofing materials.

To make your home more valuable, you can contact a Manchester roofing company to help you improve the roof. Roofing companies offer different roofing materials, each with its own advantages and drawbacks. Professional roofing contractors can help you decide what type of roof is best for your home.

Your replacement roofing should match your home's current design or architectural style. For example, if your home has a rustic feel, it might look awkward if you have sleek metal roof installed on it. Fortunately, different types of roofing Manchester contractors offer are available in various colors or designs, giving you more options.

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If you have questions, please visit us at www.AJCRoofing.com for complete details and answers.

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Guaranteed Vehicle Finance Will Allow You To To Buy Vehicle

There is no cause to think that for those who have a poor credit background that you just can by no means yet again acquire a loan to get a new or used car or truck. There are numerous special lenders now that happen to be willing to help you and this article explains.

Assured vehicle finance is readily available and you don't have to do as well considerably challenging work to acquire it. You may have lots of factors to obtain a vehicle loan however the issue is if you have a bad credit background then you'd face numerous problems in obtaining a loan. On the other hand, this doesn't imply which you can not ever get car or truck finance. You might even be self-employed and still qualify for auto finance. Here are some suggestions which will make it easier to get a car even when you've a poor credit record.

Pay Back Time

When you are negotiating the terms of the loan make sure that the payback time period is just not too long.? This can mean that you won't have to spend much more interest more than the original expense of the car or truck. The a lot more time you take the extra interest you would need to spend. But this will not imply you need to attempt and cover the whole payment in just a couple of months.? Take your time but not also considerably. You just need to be sure that the time that you are taking is producing you feel comfortable together with the total interest payable.

Take Your Time To Decide On A Deal

There are many opportunities for guaranteed auto finance.? You should take your time to determine due to the fact it may be probable which you will get a greater deal when you wait and analysis a little extra. Anyway, the bargains will not be running away and new ones are hitting the market all the time. The deal that gives you the lowest rate of interest is going to be the most effective, so attempt to come across it. Search the market place on the net for this. It is best to not be afraid to devote really a handful of hours on this but all your challenging perform are going to be worth it in case you get the ideal vehicle finance even with your negative credit condition.

Think Just before If you would like A new Vehicle Or perhaps a Used Car

This is what actually matters essentially the most. Buying a new car or truck will imply that you simply will have to borrow considerably additional funds than you would have to if you are getting a employed vehicle. A brand new auto could cost you thousands of dollars that could be out of your reach so you've to decide on sensibly. Consider it by way of, or superior however ask your lender what deal you will be provided to get a new car or truck and evaluate this with 1 to get a employed vehicle.? This can definitely make it easier to make a decision.

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There could be some penalties in your agreement and you must be aware of them. Make sure that you read the contract meticulously; there could be something relating towards the process of payment. If you do not fulfill the specifications then you may must spend a sum of funds on top rated of your normal loan repayments. The bank or lender would have the proper to charge you this since you may have signed the contract. So make sure which you know all of the facts just before you sign a guaranteed car or truck finance loan.

When you are put off from applying for a automobile finance deal due to the fact you've got a poor credit history then there is no should shy away from this. It is possible to read all about guaranteed automobile finance at http://www.msg-guaranteedcarfinance.co.uk and you will discover lots of other valuable resources there.

There are several lenders in this market now as the quantity of men and women with poor credit history has risen significantly more than the last few years. Just before agreeing to a loan be sure that you fully realize all of the terms and circumstances so that you will find no unpleasant surprises.

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Loan & Finance Blog ? Payday lenders agree to new commitments ...

May 29, 2012 at 8:51 am ? Filed under Personal Finance

Payday loans and the payday lending industry in general has been at the centre of a lot of controversy of late, with many concerned about the crippling charges coupled with the lack of adequate checks linked to payday loans and lenders. Many borrowers have found themselves in a situation where they have spiralling debts that they quickly lose control of as a result of taking out these payday loans.

It has now been reported that payday lenders have agreed to new commitments that have been designed to help struggling customers to avoid building up spiralling and unmanageable debts. If borrowers are experiencing financial difficulties and fall behind with repayments as a result of this, payday lenders will now freeze interest and charges no later than sixty days after the borrower stops making payments. Charges will also be frozen as soon as customers are able to reach an agreeable repayment plan on their outstanding balance with the lender.

The government has been informed by trade officials that the new measures will be put into place by 25th July this year. In addition to agreeing to these measures in relation to interest and charges for struggling borrowers, payday lenders have also promised to make proper, more thorough checks with regards to affordability, which could reduce the number of people taking out loans when they cannot realistically afford to repay them.

Business Minister Norman Lamb said that payday loans were designed to be used only as a short term financial stop gap and not as a long term solution to credit and finance needs. He urged consumers to think more carefully before opting for one of these short term loans and suggested that they look at more affordable options such as using a credit union.

The commitments have been made by trade associations that collectively represent around 90% of the payday lenders across the UK. Some of the member lenders are already offering similar measures to safeguard borrowers. A spokesperson for the trade associations said that the new measures and commitments would go much further in terms of safeguarding consumers than current statutory regulation.

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